New England Biolabs Canada
 

Product Pathways - Ca / cAMP / Lipid Signaling

Calreticulin Antibody #2891

Item# Description List Price Web Price Qty
2891S Calreticulin Antibody - 100 µl $383.00
$344.70
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*On-line ordering is for Canadian customers only. Web pricing is applicable only to orders placed online at www.neb.ca
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VIEW COMPANION PRODUCTS HIDE COMPANION PRODUCTS
Application Dilution Species-Reactivity Sensitivity MW (kDa) Source
W Human, Mouse, Rat, Monkey Endogenous 55 Rabbit

Species cross-reactivity is determined by western blot.

Applications Key: W=Western Blotting

Homology

Species predicted to react based on 100% sequence homology: Pig.

Protocols

Specificity / Sensitivity

Calreticulin Antibody detects endogenous levels of total calreticulin protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide surrounding Gln65 of human calreticulin. Antibodies are purified by peptide affinity chromatography.

Western Blotting

Western Blotting

Western blot analysis of extracts from HeLa and C6 cells using Calreticulin Antibody.

Background

Calcium is a universal signaling molecule involved in many cellular functions such as cell motility, metabolism, protein modification, protein folding, and apoptosis. Calcium is stored in the endoplasmic reticulum (ER), where it is buffered by calcium binding chaperones such as calnexin and calreticulin, and is released via the IP3 Receptor channel (1). Calreticulin also functions as an ER chaperone that ensures proper folding and quality control of newly synthesized glycoproteins. As such, calreticulin presumably does not alter protein folding but regulates proper timing for efficient folding and subunit assembly. Furthermore, calreticulin retains proteins in non-native conformation within the ER and targets them for degradation (2,3).

  1. Groenendyk, J. et al. (2004) Mol Cells 17, 383-9.
  2. Nauseef, W.M. et al. (1995) J Biol Chem 270, 4741-7.
  3. Williams, D.B. (2006) J Cell Sci 119, 615-23.

Application References

  • Ma, L. et al. (2012) J Biol Chem 287, 1290-305. Applications: Western Blotting.

Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know!


 

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