New England Biolabs Canada
 

Product Pathways - Apoptosis

TRAF1 Blocking Peptide #1066

Item# Description List Price Web Price Qty
1066S TRAF1 Blocking Peptide - 100 µg $458.00
$412.20
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*On-line ordering is for Canadian customers only. Web pricing is applicable only to orders placed online at www.neb.ca
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Companion Products

Item# Description List Price Web Price Qty
4715S TRAF1 (45D3) Rabbit mAb - 100 µl $372.00
$334.80
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4715T TRAF1 (45D3) Rabbit mAb - 20 µl $159.00
$143.10
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This product is assembled upon order. Please allow up to three weeks for your product to be processed.

Description

This peptide is used to block TRAF1 (45D3) Rabbit mAb #4715 reactivity in dot blot protocols.

Quality Control

The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry. The peptide blocks TRAF1 (45D3) Rabbit mAb #4715 signal in dot blot.

Directions For Use

Use as a blocking reagent to evaluate the specificity of antibody reactivity in dot blot protocols.

Background

TRAFs (TNF receptor-associated factors) are a family of multifunctional adaptor proteins that bind to surface receptors and recruit additional proteins to form multiprotein signaling complexes capable of promoting cellular responses (1-3). Members of the TRAF family share a common carboxy-terminal "TRAF domain", which mediates interactions with associated proteins; many also contain amino-terminal Zinc/RING finger motifs. The first TRAFs identified, TRAF1 and TRAF2, were found by virtue of their interactions with the cytoplasmic domain of TNF-receptor 2 (TNFRII) (4). The six known TRAFs (TRAF1-6) act as adaptor proteins for a wide range of cell surface receptors and participate in the regulation of cell survival, proliferation, differentiation, and stress responses.

  1. Arch, R.H. et al. (1998) Genes Dev 12, 2821-30.
  2. Chung, J.Y. et al. (2002) J Cell Sci 115, 679-88.
  3. Bradley, J.R. and Pober, J.S. (2001) Oncogene 20, 6482-91.
  4. Rothe, M. et al. (1994) Cell 78, 681-92.

Application References

Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know!


 

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