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DAZL (D2A4) Rabbit mAb (IHC Specific) #13057

Item# Description List Price Web Price Qty
13057S DAZL (D2A4) Rabbit mAb (IHC Specific) - 100 µl $372.00
$334.80
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*On-line ordering is for Canadian customers only. Web pricing is applicable only to orders placed online at www.neb.ca
VIEW COMPANION PRODUCTS HIDE COMPANION PRODUCTS
Application Dilution Species-Reactivity Sensitivity MW (kDa) Isotype
IHC-P Human, Mouse Endogenous 38 Rabbit IgG

Species cross-reactivity is determined by the application specified.

Applications Key: IHC-P=Immunohistochemistry (Paraffin)

Homology

Species predicted to react based on 100% sequence homology: Rat.

Specificity / Sensitivity

DAZL (D2A4) (IHC Specific) Rabbit mAb recognizes endogenous levels of total DAZL protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human protein.

IHC-P (paraffin)

IHC-P (paraffin)

Immunohistochemical analysis of paraffin-embedded mouse testes (left) and mouse kidney (right) using DAZL (D2A4) Rabbit mAb (IHC Specific). As expected, kidney is DAZL negative.

IHC-P (paraffin)

IHC-P (paraffin)

Immunohistochemical analysis of paraffin-embedded human testes using DAZL (D2A4) Rabbit mAb (IHC Specific) in the presence of control peptide (left) or antigen-specific peptide (right).

Background

The human DAZ (Deleted in Azoospermia) gene family contains at least three members that encode RNA-binding proteins with a common RNA-recognition motif (1). An autosomal homolog of DAZ, DAZL (DAZ-like), is specifically expressed in germ cells and is essential for the specification of the germ cell lineage during embryogenesis and during gametogenesis in adults of both sexes (2,3). DAZL may function by directly recruiting poly(A)-binding proteins (PABPs) in order to activate silent mRNAs during germ cell development (2). Deletions encompassing the Y chromosomal DAZ genes are the most common molecularly defined cause of infertility in humans (4,5).

  1. Yen, P.H. (2004) Int J Androl 27, 125-9.
  2. Collier, B. et al. (2005) EMBO J 24, 2656-66.
  3. Brook, M. et al. (2009) Reproduction 137, 595-617.
  4. Reijo, R. et al. (1995) Nat Genet 10, 383-93.
  5. Cooke, H.J. and Elliott, D.J. (1997) Trends Genet 13, 87-9.

Application References

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