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Product Pathways - Ca / cAMP / Lipid Signaling

Calretinin (E9R6G) Rabbit mAb #17114

Item# Description List Price Web Price Qty
17114S Calretinin (E9R6G) Rabbit mAb - 100 µl $364.00
$327.60
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VIEW COMPANION PRODUCTS HIDE COMPANION PRODUCTS
Application Dilution Species-Reactivity Sensitivity MW (kDa) Isotype
W Human, Mouse, Rat Endogenous 29 Rabbit IgG
IP

Species cross-reactivity is determined by western blot.

Applications Key: W=Western Blotting, IP=Immunoprecipitation

Specificity / Sensitivity

Calretinin (E9R6G) Rabbit mAb recognizes endogenous levels of total Calretinin protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu149 of human Calretinin protein.

Western Blotting

Western Blotting

Western blot analysis of extracts from various tissues and cell lines using Calretinin (E9R6G) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).

IP

IP

Immunoprecipitation of Calretinin protein from mouse brain tissue extracts. Lane 1 is 10% input, lane 2 is Rabbit (DA1E) mAb IgG XP® Isotype Control #3900, and lane 3 is Calretinin (E9R6G) Rabbit mAb. Western blot analysis was performed using Calretinin (E9R6G) Rabbit mAb as the primary antibody and using a light chain specific secondary antibody.

Background

Calretinin (29 kDa calbindin, calbindin 2) is a calcium-binding protein of the EF-hand family encoded by the CALB2 gene. It is differentially expressed from homologous family member calbindin-d28k in distinct neuronal populations of the retina, auditory system, and cerebellar granule cells (1, 2), and acts as a marker for specific neuronal subsets of the subthalamic nucleus and the substantia nigra (3). Calretinin has been shown to play an important role in modulating neuronal excitability and the induction of long-term potentiation (1). Research has shown that, pathologically, calretinin is a selective marker for epithelial mesothelioma, making it a diagnostic tool to differentiate from adenocarcinomas (4).

  1. Camp, A.J. and Wijesinghe, R. (2009) Int J Biochem Cell Biol 41, 2118-21.
  2. Rogers, J.H. (1987) J Cell Biol 105, 1343-53.
  3. Fortin, M. and Parent, A. (1996) Brain Res 708, 201-4.
  4. Gotzos, V. et al. (1996) Pathol Res Pract 192, 137-47.

Application References

Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know!


 

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