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Product Pathways - Lymphocyte Signaling

PVR/CD155 (D8A5G) Rabbit mAb #81254

Item# Description List Price Web Price Qty
81254S PVR/CD155 (D8A5G) Rabbit mAb - 100 µl $385.00
$346.50
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*On-line ordering is for Canadian customers only. Web pricing is applicable only to orders placed online at www.neb.ca
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VIEW COMPANION PRODUCTS HIDE COMPANION PRODUCTS
Application Dilution Species-Reactivity Sensitivity MW (kDa) Isotype
W Human Endogenous 60-80 Rabbit IgG
IHC-Bond
IHC-P

Species cross-reactivity is determined by western blot.

Applications Key: W=Western Blotting, IHC-Bond=IHC-Leica® Bond™, IHC-P=Immunohistochemistry (Paraffin)

Specificity / Sensitivity

PVR/CD155 (D8A5G) Rabbit mAb recognizes endogenous levels of total CD155 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asn188 of human CD155 protein.

Western Blotting

Western Blotting

Western blot analysis of extracts from various cell lines using PVR/CD155 (D8A5G) Rabbit mAb (upper) and β-actin (D6A8) Rabbit mAb #8457 (lower).

IHC-Leica® Bond™

IHC-Leica® Bond™

Immunohistochemical analysis of paraffin-embedded human colon adenocarcinoma using PVR/CD155 (D8A5G) Rabbit mAb performed on the Leica® Bond™ Rx.

IHC-P (paraffin)

IHC-P (paraffin)

Immunohistochemical analysis of paraffin-embedded human breast carcinoma using PVR/CD155 (D8A5G) Rabbit mAb.


IHC-P (paraffin)

IHC-P (paraffin)

Immunohistochemical analysis of paraffin-embedded A549 cell pellet (left, positive) and Daudi cell pellet (right, negative) using PVR/CD155 (D8A5G) Rabbit mAb.

IHC-P (paraffin)

IHC-P (paraffin)

Immunohistochemical analysis of paraffin-embedded human prostate carcinoma using PVR/CD155 (D8A5G) Rabbit mAb.

Background

Poliovirus receptor (PVR, CD155) is an immunoglobulin-like, transmembrane glycoprotein originally described as a mediator of poliovirus attachment to cells and later identified as important in adherens junction formation. Also known as nectin-like 5 (Necl-5), PVR binds nectin-3 and interacts with integrin αvβ3 and PDGFR to regulate integrin clustering and focal contact formation at the leading edge of migrating cells (1,2). Research studies demonstrate that PVR and nectin-3 regulate contact inhibition during cell motility and proliferation in transformed 3T3 cells (3). Additional research indicates that PVR (CD155, Necl-5) expression may play a role in invasiveness of lung adenocarcinoma (4,5). In the immune system, CD155 plays a role in natural killer (NK) cell-mediated cytotoxicity (6).

  1. Takai, Y. et al. (2008) Nat Rev Mol Cell Biol 9, 603-15.
  2. Sakisaka, T. et al. (2007) Curr Opin Cell Biol 19, 593-602.
  3. Minami, Y. et al. (2007) Biochem Biophys Res Commun 352, 856-60.
  4. Tane, S. et al. (2013) Exp Mol Pathol 94, 330-5.
  5. Nakai, R. et al. (2010) Cancer Sci 101, 1326-30.
  6. Stanietsky, N. and Mandelboim, O. (2010) FEBS Lett 584, 4895-900.

Application References

Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know!


 

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