New England Biolabs Canada
 

Product Pathways - Lymphocyte Signaling

LAIR-1 Antibody #87923

Item# Description List Price Web Price Qty
87923S LAIR-1 Antibody - 100 µl $372.00
$334.80
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*On-line ordering is for Canadian customers only. Web pricing is applicable only to orders placed online at www.neb.ca
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Application Dilution Species-Reactivity Sensitivity MW (kDa) Source
W Human Endogenous 40-60 Rabbit
IP

Species cross-reactivity is determined by western blot.

Applications Key: W=Western Blotting, IP=Immunoprecipitation

Specificity / Sensitivity

LAIR-1 Antibody recognizes endogenous levels of total LAIR-1 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxyterminus of human LAIR-1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Western Blotting

Western Blotting

Western blot analysis of extracts from THP-1 and CCRF-CEM cells using LAIR-1 Antibody.

IP

IP

Immunoprecipitation of LAIR-1 from THP-1 cell extracts. Lane 1 is 10% input, lane 2 is Normal Rabbit IgG #2729, and lane 3 is LAIR-1 Antibody. Western blot analysis was performed using LAIR-1 Antibody. Anti-rabbit IgG, HRP-linked Antibody #7074 was used as secondary antibody.

Background

LAIR-1 is an inhibitory receptor that belongs to the Immunoglobulin superfamily. It has one extracellular Ig-like domain and an intracellular C-terminus with two ITIM (immunoreceptor tyrosine-based inhibitory motif) domains. It is found on peripheral mononuclear cells, including NK, T, and B cells, and is thought to play a negative regulatory role on the cytolytic function of these cells through signaling through collagen ligation (1). LAIR1 has been noted to be upregulated in renal cell carcinoma (2), and may play a role in expansion of Th17 cell populations in collagen-rich environments, such as in graft rejection tissue (3).

  1. Meyaard, L. (2008) J Leukoc Biol 83, 799-803.
  2. Jingushi, K. et al. (2019) Oncol Rep 41, 1293-303.
  3. Agashe, V.V. et al. (2018) J Immunol 201, 772-81.

Application References

Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know!


 

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