New England Biolabs Canada

Product Pathways - Innate Immunity

Mannose Receptor Antibody #12981

Item# Description List Price Web Price Qty
12981S Mannose Receptor Antibody - 100 µl $372.00
*On-line ordering is for Canadian customers only. Web pricing is applicable only to orders placed online at
Application Dilution Species-Reactivity Sensitivity MW (kDa) Source
W Human Endogenous 190 Rabbit

Species cross-reactivity is determined by western blot.

Applications Key: W=Western Blotting


Specificity / Sensitivity

Mannose Receptor Antibody recognizes endogenous levels of total mannose receptor protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu115 of human mannose receptor protein. Antibodies are purified by protein A and peptide affinity chromatography.

Western Blotting

Western Blotting

Western blot analysis of extracts from various cell lines using Mannose Receptor Antibody (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).


The mannose receptor (MR/CLEC13D/CD206/MMR/MRC1/Macrophage mannose receptor 1) is an endocytic receptor expressed by populations of dendritic cells, macrophages and nonvascular endothelium (1). The mannose receptor is a heavily glycosylated type I transmembrane protein with three types of extracellular domains and a short carboxy-terminal cytoplasmic domain with no apparent signaling motif (2-4). The extracellular portion of the protein is made up of a CR domain, which binds sulfated glycans, an FNII domain, which binds collagens, and eight C-type lectin domains, which bind carbohydrates containing mannose, fucose or GlcNAc (4-7). The receptor recycles between the plasma membrane and early endosomes (8). Functions include a role in antigen cross-presentation, clearance of endogenous proteins, pathogen detection and trafficking through lymphatic vessels (9-12).

  1. Martinez-Pomares, L. (2012) J Leukoc Biol 92, 1177-86.
  2. Lennartz, M.R. et al. (1989) J Biol Chem 264, 2385-90.
  3. Wileman, T.E. et al. (1986) Proc Natl Acad Sci U S A 83, 2501-5.
  4. Taylor, M.E. et al. (1990) J Biol Chem 265, 12156-62.
  5. Fiete, D.J. et al. (1998) Proc Natl Acad Sci U S A 95, 2089-93.
  6. Napper, C.E. et al. (2006) Biochem J 395, 579-86.
  7. Fiete, D. et al. (1997) Proc Natl Acad Sci U S A 94, 11256-61.
  8. Tietze, C. et al. (1982) J Cell Biol 92, 417-24.
  9. Burgdorf, S. et al. (2006) J Immunol 176, 6770-6.
  10. Lee, S.J. et al. (2002) Science 295, 1898-901.
  11. Milone, M.C. and Fitzgerald-Bocarsly, P. (1998) J Immunol 161, 2391-9.
  12. Marttila-Ichihara, F. et al. (2008) Blood 112, 64-72.

Application References

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